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Overall, the results of this meta-analysis show that duloxetine is effective in reducing opioid consumption and pain intensity with no significant differences in adverse event rates, except for somnolence which was significantly lower in the control group. The study also found that duloxetine significantly reduced postoperative pain, but the observed benefits did not meet the minimum clinically important difference (MCID) of 1.3 points on an 11-point scale, questioning its clinical efficacy in pain management protocols. Despite statistical significance, the pain relief effects were below the MCID threshold as stated by the literature, highlighting a potential gap between statistical and clinical relevance. The results of this meta-analysis were limited by a small number of included studies, a high risk of bias, and considerable heterogeneity in duloxetine doses among the included studies.