Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study

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研究概要

Ninety-seven patients reporting moderate pain from knee osteoarthritis were randomized to receive 8 weeks of daily dietary supplementation with a oral mixture of hyaluronic acid, glucosamine, and chondroitin (n=47) or an oral placebo (n=50). The primary outcome of interest was the change from baseline in Knee Injury and Osteoarthritis Outcomes Scores (KOOS). Secondary outcomes of interest included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Short Form 36 (SF-36) quality of life questionnaire, and the Chinese version of Pittsburgh Sleep Quality Index (CPSQI). Outcomes were assessed after completion of the intervention period. No significant differences in all outcomes were observed between the two groups.