Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers .
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Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers
Psychopharmacology (Berl). 2008 23-Feb;():. 10.1007/s00213-007-0963-0Twenty-two healthy subjects underwent a randomized, placebo-controlled, double-blind crossover study to test the effects of ayahuasca on the sleep/wake cycle. Subjects received placebo, a ayahuasca dose and 20 mg of d-amphetamine as a positive control. Subjective sleep quality, polysomnography (PSG), and spectral analysis measures were assessed. Compared to d-amphetamine, ayahuasca did not induce subjectively perceived deterioration of sleep quality or PSG-measured disruptions of sleep initiation or maintenance. Ayahuasca inhibited rapid eye movement (REM) sleep and increased power in the high frequency range during stage 2. Ayahuasca enhanced power in the slow-wave sleep frequency band in the first night cycle.
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