Increased frontal and paralimbic activation following ayahuasca, the pan-Amazonian inebriant .
Increased frontal and paralimbic activation following ayahuasca, the pan-Amazonian inebriant
Psychopharmacology (Berl). 2006 23-Feb;():. 10.1007/s00213-006-0358-7Fifteen healthy subjects underwent a randomized, placebo-controlled, double-blind trial to test the effects of ayahuasca on regional cerebral blood flow. Subjects received a single oral dose of ayahuasca and regional blood flow was measured through single photo emission tomography (SPECT). Ayahuasca administration induced significant activation of frontal and paralimbic brain regions. Increased blood perfusion was observed bilaterally in the anterior insula, with greater intensity in the right hemisphere and in the anterior cingulate/frontomedial cortex of the right hemisphere.
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