Complications of Platelet-Rich Plasma Injection for Knee Osteoarthritis Are Similar to Those of Corticosteroids and Hyaluronic Acid but Are Significantly Greater Than Those of Placebo Injections: A Meta-analysis of Randomized Controlled Trials.

Questo studio è stato identificato come potenzialmente ad alto impatto. La metrica High Impact di OE, guidata dall'AI, stima l'influenza che un articolo potrebbe avere integrando i segnali della rivista in cui è stato pubblicato e il contenuto scientifico dell'articolo stesso. Sviluppato utilizzando un'elaborazione del linguaggio naturale all'avanguardia, il modello High Impact di OE prevede in modo più accurato la futura performance citazionale di uno studio rispetto al solo fattore di impatto della rivista. Ciò consente di riconoscere prima le ricerche clinicamente significative e aiuta i lettori a concentrarsi sugli articoli che hanno maggiori probabilità di influenzare la pratica futura.

Riassunto dello studio

Twenty-four randomized controlled trials including 2751 patients with knee osteoarthritis (KOA) were included in this systematic review and meta-analysis comparing platelet-rich plasma (PRP) injections with hyaluronic acid (HA), corticosteroids, placebo saline solution, bone marrow aspirate concentrate, prolotherapy, and contrast injections. Pooled outcomes of interest included overall complication rates, post-injection pain, joint effusion, synovitis, other medical adverse events, and complication severity. Overall, complications occurred significantly more frequently after PRP injections than comparator injections. PRP demonstrated similar odds of complications compared with HA and corticosteroid injections but significantly greater odds compared with placebo saline injections. Most complications were mild to moderate and self-limiting, with only one report of severe pain. The findings suggest that PRP injections for knee osteoarthritis are associated with a meaningful increase in adverse events relative to placebo, although their safety profile appears comparable to other commonly used injectable therapies.