Ten randomized trials involving 797 patients undergoing total knee arthroplasty were included in this meta-analysis comparing adductor canal block and local infiltration anesthesia vs. local infiltration anesthesia alone. The primary outcomes of interest were pain at rest and during walking on a Visual Analog Scale (VAS), morphine consumption, range of motion, and distance walked. Secondary outcomes of interest included length of stay, nausea and vomiting, and the incidence of complications. Pooled results revealed significantly lower VAS resting pain at 24 hours, walking pain at 24 hours and 48 hours, and morphine consumption at 48 hours in the combination group. Moreover, range of motion at 24 hours was significantly in favour of the combination group. No other differences were observed.