Collagen meniscus implant adequate to enhance meniscal function in chronic meniscal injury .
This report has been verified
by one or more authors of the
original publication.
Este estudio ha sido identificado como potencialmente de alto impacto.
La métrica de alto impacto de OE, impulsada por la IA, estima la influencia que probablemente tendrá un artículo integrando señales tanto de la revista en la que se publica como del contenido científico del propio artículo.
Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo.
Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(2):225 J Bone Joint Surg Am. 2008 Jul;90(7):1413-26.311 patients with an irreparable injury of the medial meniscus or a previous partial medial meniscectomy were divided into 2 study arms: acute arm with no prior surgery on the involved meniscus or the chronic arm with 1, 2 or 3 prior meniscal surgeries. Patients were randomized either to receive the collagen meniscus implant or to be treated with a partial meniscectomy only. Clinical follow-up examinations were performed for 2 years postoperatively, and patients were to complete validated questionnaires 7 years postoperatively. Patients allocated to receive the collagen meniscus implant also underwent 1-year second-look arthroscopy to assess tissue growth and quality. Results indicated that the collagen meniscus implant was found to support new tissue ingrowth, which was stable, safe, and biomechanically competent and improved meniscal function, as evident by the clinical outcomes in patients with a chronic meniscal injury.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Sí = 1
Incierto = 0,5
No relevante = 0
No = 0
La evaluación de los criterios de información evalúa la transparencia con la que los autores informan de las características metodológicas y del ensayo dentro de la publicación. La evaluación se divide en cinco categorías que se presentan a continuación.
3/4
Randomization
2/4
Outcome Measurements
4/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
El Índice de Fragilidad es una herramienta que ayuda en la interpretación de hallazgos significativos, proporcionando una medida de fuerza para un resultado. El Índice de Fragilidad representa el número de eventos consecutivos que es necesario añadir a un resultado dicotómico para que el hallazgo deje de ser significativo. Un número pequeño representa un hallazgo más débil y un número grande un hallazgo más fuerte.
¿Por qué se necesitaba ahora este estudio?
Meniscal injuries lead to increased pain and limitation in clinical function and activity levels. The options in this field are very limited, with cadaver grafts having limited applications. The Biomaterials research evaluates the newer materials for collagen meniscus implant application and it is unclear whether such implant would have a clinical role in future. This study was needed to evaluate the efficacy of the collagen meniscus implant in chronic and acute patients.
¿Cuál era la pregunta principal de la investigación?
Does the application of collagen meniscus implant have superior clinical outcomes as compared to patients treated with partial medial meniscectomy alone, for irreparable injury of medial meniscus, as evaluated over 7 years?
- At 1 year, the 141 repeat arthroscopies that were performed revealed that the collagen meniscus implants had resulted in significantly increased meniscal tissue over that seen after the partial meniscectomy (p=0.001).
- The implant was found to flourish the meniscus-like matrix production and integration, as it was assimilated and resorbed.
- In the chronic study arm, the patients receiving meniscal implant significantly regained much of their lost activity than controls (p=0.02) and also underwent significantly lesser reoperations (p=0.04).
- No differences were observed between the two study groups in the acute arm.
¿Qué es lo que más debo recordar?
The collagen meniscus implant was found to support new tissue ingrowth, which was stable, safe, bio-mechanically competent and improved meniscal function, as evident by the improved clinical outcomes in patients with a chronic meniscal injury.
¿Cómo afectará esto al cuidado de mis pacientes?
The collagen meniscus implant has a potential future in replacing the irreparable or lost meniscal tissue and hence improving the quality of life in patients with chronic meniscal injury. Definitive determination of the effect of collagen meniscus implants should be achieved with future research.
DESCARGO DE RESPONSABILIDAD
El contenido de esta página tiene únicamente fines informativos y no pretende sustituir el consejo, diagnóstico o tratamiento médico profesional. Si necesita tratamiento médico, busque siempre el consejo de su médico o acuda al servicio de urgencias más cercano. Las opiniones, creencias y puntos de vista expresados por las personas sobre el contenido que se encuentra en esta página no reflejan las opiniones, creencias y puntos de vista de OrthoEvidence.
0 de 4 artículos mensuales GRATIS desbloqueados
