Changes in brain connectivity in LSD-induced altered states of consciousness. .
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Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor
Elife. 2018 23-Feb;():. 10.7554/eLife.35082Twenty-four healthy subjects underwent a double-blind, randomized, counterbalanced, cross-over study design to test the neurobiological effects of LSD acting on serotonin receptors. Subjects received combinations of either placebo, LSD, and ketanserin (a serotonin receptor antagonist). fMRI was used to quantify resting-state functional connectivity via the global brain connectivity method. LSD increased sensory-somatomotor brain-wide and thalamic connectivity while reducing associative connectivity. Ketanserin fully blocked the subjective and neural LSD effects.
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