Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(14):11 Elife. 2018 23-Feb;():. 10.7554/eLife.35082What this means for my practice?
LSD produces widespread alterations of GBC, characterized by synchronization of sensory and somatomotor functional networks and dis-integration of associative networks. Whole-brain spatial patterns of LSD effects matched 5-HT2A receptor cortical gene expression, indicating the role that the 5-HT2A receptor plays in subjective and neuronal LSD-induced effects. The results are limited by the small sample size.
Study Summary
Twenty-four healthy subjects underwent a double-blind, randomized, counterbalanced, cross-over study design to test the neurobiological effects of LSD acting on serotonin receptors. Subjects received combinations of either placebo, LSD, and ketanserin (a serotonin receptor antagonist). fMRI was used to quantify resting-state functional connectivity via the global brain connectivity method. LSD increased sensory-somatomotor brain-wide and thalamic connectivity while reducing associative connectivity. Ketanserin fully blocked the subjective and neural LSD effects.
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