Celecoxib vs. diclofenac plus omeprazole for OA or RA treatment with lesser GI risk .
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Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
Lancet. 2010 Jul 17;376(9736):173-9. Epub 2010 Jun 164484 cardiovascularly healthy patients with a clinical diagnosis of osteoarthritis or rheumatoid arthritis were randomized to be treated with either selective cox-2 inhibitor NSAID (celecoxib) or a combination of non-selective NSAID (diclofenac) and a proton pump inhibitor (omeprazole) for at least 6 months. After 6 months of treatment observation period, the rate of clinically significant GI events was 4 times higher in patients receiving diclofenac plus omeprazole over celecoxib. Subjective patient assessment via the Patient's Global Assessment of Arthritis showed no significant difference.
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