Celecoxib decreases post-operative pain and lowers morphine consumption after TKR .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(11):94 Acta Orthop. 2007 Oct;78(5):661-750 patients requiring total knee replacement (TKR) were randomized to receive either a placebo, or Celecoxib (200mg) preoperatively and twice daily for 3 weeks postoperatively. The primary outcome examined was perioperative blood loss, and other subjective factors were reviewed. Results demonstrated that Celecoxib does not increase perioperative blood loss, but decreases post-operative pain and opioid consumption.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Ja = 1
Ungewiss = 0.5
Nicht relevant = 0
Nein = 0
Die Bewertung der Berichtskriterien bewertet die Transparenz, mit der die Autoren die methodischen und studienspezifischen Merkmale der Studie in der Veröffentlichung angeben. Die Bewertung ist in fünf Kategorien unterteilt, die im Folgenden vorgestellt werden.
4/4
Randomization
4/4
Outcome Measurements
2/4
Inclusion / Exclusion
4/4
Therapy Description
0/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
Der Fragilitätsindex ist ein Instrument, das bei der Interpretation signifikanter Ergebnisse hilft und ein Maß für die Stärke eines Ergebnisses liefert. Der Fragilitätsindex gibt die Anzahl der aufeinanderfolgenden Ereignisse an, die zu einem dichotomen Ergebnis hinzugefügt werden müssen, damit das Ergebnis nicht mehr signifikant ist. Eine kleine Zahl steht für ein schwächeres Ergebnis und eine große Zahl für ein stärkeres Ergebnis.
Warum wurde diese Studie jetzt benötigt?
Non-steroidal anti-inflammatory drugs can be used preoperatively and postoperatively as an analgesic, but its use is often discontinued prior to surgical treatment due to the belief that it increases perioperative blood loss. COX-2 inhibitors, a form of non-steroidal anti-inflammatory drug (NSAID), can be used for pain management, but there is uncertainty on its positive and negative effects. This study examines the effect of Celecoxib, a COX-2 inhibitor on perioperative and postoperative outcomes (blood loss, pain, analgesic requirement, range of motion and other subjective outcomes) in total knee replacement (TKR).
Was war die wichtigste Forschungsfrage?
What are the clinical and subjective perioperative and postoperative outcomes of Celecoxib (a COX-2 inhibitor) in patients undergoing total knee replacement (TKR) surgery?
- There were no significant differences seen in total, drainage or hidden blood loss between the intervention (Celecoxib) and placebo group. The total blood loss for the placebo group was 810 mL compared to 733 mL for the Celecoxib group. (95%CI= -1.6-11.6)
- The intervention group reported 30% lower pain scores compared to the placebo group during the first 4 weeks postoperatively.
- The intervention group also reported lower opioid consumption postoperatively (6 SD 6 mg vs. 10 SD 7 mg; 95% CI -9.5 to -2.5).
- At the 1-year follow-up, no effect was seen on range of motion, pain, and subjective outcomes.
- No deep infections or wound complications were seen during the first year postoperatively, but one patient from the placebo group sustained a bilateral deep vein thrombosis at 1 month postoperatively. The patient was treated successfully with warfarin.
- KOOS values improved from preoperation measurements in both groups at 3 and 12 months, but the difference between groups was not significant
Was sollte ich mir besonders merken?
The use of Celecoxib did not induce increased blood loss perioperatively, but reduced postoperative pain after total knee replacement (TKR) surgery. At the one-year follow-up, pain, range of motion and subjective outcomes (KOOS score) did not improve following the postoperative use of Celecoxib.
Wie wird sich dies auf die Behandlung meiner Patienten auswirken?
Patients undergoing total knee replacement (TKR) may find short-term pain relief postoperatively when taking Celecoxib. However, significant results/improvements may not be seen at 1 year. Further studies are being performed by the authors to examine the effect of Celecoxib on early prosthesis fixation.
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