64 patients with plantar fasciitis were randomized to receive ultrasound-guided injections of Botulinum toxin A (BTX-A; n=22) or Platelet Rich Plasma (PRP; n=23) or to undergo conservative stretching-based treatment (control; n=19). Outcomes of interest were pain relief measured by the Visual Analogue Scale (VAS), functional recovery assessed by the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale, Foot and Ankle Ability Measure (FAAM) questionnaire, and reduction in plantar fascia thickness. Outcomes were assessed up to 12 months. Overall, the results of the study revealed that both BTX-A and PRP injections effectively reduced pain and improved function, with BTX-A showing better short-term outcomes and PRP demonstrating superior long-term benefits. The study highlights the effectiveness of both treatment modalities in managing chronic plantar fasciitis, suggesting a tailored approach based on the duration of symptom relief desired.