Bone Marrow Buffy Coat vs B-tricalcium Phosphate Granules for Avascular Necrosis of the Femoral Head .
Combining autologous bone marrow buffy coat and angioconductive bioceramic rod grafting with advanced core decompression improves short-term outcomes in early avascular necrosis of the femoral head: a prospective, randomized, comparative study
Stem Cell Res Ther. 2021 Jun 19;12(1): 354.Forty-four patients (57 hips) with avascular necrosis of the femoral head were randomized to receive hip preservation surgery with advanced core decompression and angioconductive bioceramic rod grafting plus either bone marrow aspirated buffy coat (n=18; 24 hips) or beta-tricalcium phosphate granules (n=26; 33 hips). The primary outcome of interest was Harris Hip Scores (HHS) after surgery. The secondary outcome of interest was the rate of clinical failures of the operated hips. Results revealed significantly favourable HHS scores in the buffy coat grafting group compared to the control group (p=0.041). No significant difference was observed in the rate of clinical failure between the two groups (p>0.05).
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