Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Reconstruction .
Bone Marrow Aspirate Concentrate Augmentation May Accelerate Allograft Ligamentization in Anterior Cruciate Ligament Reconstruction: A Double-Blinded Randomized Controlled Trial
Arthroscopy . 2022 Jul;38(7):2255-2264.Eighty patients undergoing anterior cruciate ligament reconstruction (ACLR) were randomized to receive either a bone marrow aspirate concentrate (BMAC; n=40) or a standard ACLR procedure (n=40). The primary endpoint of this trial was magnetic resonance imaging (MRI) intensities at 3 and 9 months, postoperatively. Patient-reported outcomes such as the International Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Score for Joint Replacement (KOOS-JR), and Tegner scores were assessed. Other outcomes such as range of motion were also assessed at 6 weeks, 3, 6, 9, and 12 months post-operatively. Patients in the BMAC group showed greater MRI signal intensity scores at 3 months and significantly better IKDC scores at 9 months follow-up, compared to the sham treatment group.
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