Blood transfusion: No direct effect on delirium severity following hip fracture surgery .
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Delirium outcomes in a randomized trial of blood transfusion thresholds in hospitalized older adults with hip fracture
J Am Geriatr Soc. 2013 Aug;61(8):1286-95139 participants, age 50 or older, hospitalized with a hip fracture and experiencing cardiovascular disease or risk factors and hemoglobin concentrations of less than 10 g/dL, were randomized into 1 of 2 groups, to discover the effect of blood transfusion on post-operative delirium. The Liberal treatment group, which contained patients who received one unit of packed red blood cells, and as much blood as needed to maintain a hemoglobin concentration greater than 10g/dL during hip surgery, or the Restrictive group, where participants received a transfusion if they developed symptoms of anemia or if, at the study physician’s discretion, their hemoglobin concentration was below 8g/dL. Results showed that delirium severity or occurrence after hip fracture surgery was not affected by blood transfusion (5 days after completion of surgery).
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