Thirty athletes with chronic ankle instability (CAI) were randomized to receive either blood flow restriction training (BFRT) combined with instrument-assisted soft tissue mobilization (IASTM) (n=15) or traditional ankle strength and stability training (n=15). The primary outcome was ankle stability measured using the Cumberland Ankle Instability Tool (CAIT). Secondary outcomes included ankle function (FAAM-ADL and FAAM-SPORT), range of motion, and strength. Outcomes were assessed at pre-intervention, immediately post-intervention, and after 4 weeks. Overall, the results showed that both groups achieved significant improvements in stability, strength, and range of motion (P<0.05), but the test group demonstrated superior results in CAIT scores, FAAM-SPORT scores, and specific range of motion parameters. The findings suggest that BFRT combined with IASTM enhances rehabilitation outcomes more effectively than traditional training for CAI athletes​.