Biochemical markers of bone and cartilige degradation associated with progression of OA .
Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: The Knee Osteoarthritis Structural Arthritis randomized clinical trial
Osteoarthritis Cartilage. 2008 Jun;16(6):660-6. Epub 2007 Nov 13.2483 patients were recruited to two parallel studies in North America (NA) and Europe (EU) to assess the effect of the structure modifying anti-OA drug, risedronate, on bone and cartilage degradation markers and radiological progression of OA. At 6 months, there was a dose-dependent induced reduction in markers of cartilage and bone degradation that was maintained until 24 months follow-up. Radiological progression of knee OA, as measure by change in joint space width (JSW), was associated with CTX-II levels throughout the study.
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