Autonomic, neuroendocrine, and immunological effects of ayahuasca: a comparative study with d-amphetamine

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

Ten healthy participants were included in this double-blind, randomized, crossover trial investigating the autonomic, neuroendocrine, and immunomodulatory effects of ayahuasca. Participants were administered placebo, 20 mg D-amphetamine, or ayahuasca containing 1 mg/kg of N,N-dimethyltryptamine (DMT) in three study sessions with a washout period of at least one week between sessions. Subjective drug effects were measured using the Hallucinogen Rating Scale (HRS) and the Addiction Research Center Inventory (ARCI) questionnaires. Electrical brain activity was measured using EEG. Body temperature and pupillary diameter were also assessed. Lymphocyte subpopulations were quantified from blood samples, as were serum growth hormone (GH) and prolactin levels which were determined through chemiluminescent and electrochemiluminescent immunoassay. Results show that ayahuasca displayed moderate sympathomimetic effects, significant neuroendocrine stimulation, and a time-dependent modulatory effect on cell-mediated immunity.