Aspirin vs Low-Molecular-Weight Heparin for Venous Thromboembolism Prophylaxis after TKA .
The role of aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis after total knee arthroplasty: a meta-analysis of randomized controlled trials.
Int J Surg . 2023 Nov 1;109(11):3648-3655.In this systematic review and meta-analysis, six studies of 6772 patients who received prophylactic anticoagulant therapy after total knee arthroplasty (TKA) were analysed to compare aspirin versus low-molecular-weight heparin (LMWH). Pooled outcomes of interest included the incidence of VTE, deep venous thrombosis (DVT), pulmonary embolism (PE), as well as bleeding complications rates. The pooled results indicated that LMWH significantly reduced the overall rate of suffering from VTE compared to aspirin (RR 1.46, 95% CI: 1.16–1.84). However, there were no significant differences in DVT, PE, and bleeding complications rates between aspirin and LMWH.
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