The effect of adjuvant midazolam compared with fentanyl on the duration of spinal anesthesia with 0.5% bupivacaine in opium abusers

This report has been verified by one or more authors of the original publication.

90 opium abuser patients undergoing lower limb orthopedic surgery were randomized in order to determine which adjuvant is the most effective in providing a spinal block. Patients received 15 mg plain bupivacaine, 15 mg bupivacaine plus 25 mcg fentanyl, or 15 mg bupivacaine plus 1 mg midazolam. When assessed after the first 24 hours, patients receiving bupivacaine with midazolam had the longest sensory block duration and required the least morphine. This was followed by bupivacaine with fentanyl, and then lastly plain bupivacaine.