Adjuvant midazolam provides longer duration of sensory block in opium abusers .
This report has been verified
by one or more authors of the
original publication.
The effect of adjuvant midazolam compared with fentanyl on the duration of spinal anesthesia with 0.5% bupivacaine in opium abusers
Korean J Anesthesiol. 2012 Dec;63(6):521-6. doi: 10.4097/kjae.2012.63.6.521. Epub 2012 Dec 1490 opium abuser patients undergoing lower limb orthopedic surgery were randomized in order to determine which adjuvant is the most effective in providing a spinal block. Patients received 15 mg plain bupivacaine, 15 mg bupivacaine plus 25 mcg fentanyl, or 15 mg bupivacaine plus 1 mg midazolam. When assessed after the first 24 hours, patients receiving bupivacaine with midazolam had the longest sensory block duration and required the least morphine. This was followed by bupivacaine with fentanyl, and then lastly plain bupivacaine.
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