Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

Twenty healthy subjects participated in this randomised, placebo-controlled, double-blind, cross-over study aimed at investigating the acute effects of lysergic acid diethylamide (LSD) on the neural substrate of emotional processing in humans. Participants completed two study sessions in which they were orally administered placebo or 100 μg LSD with a washout period of at least 7 days between sessions. Outcomes were brain activity measured by functional MRI during a facial expression paradigm task, subjective drug effects measured on a visual analogue scale, and LSD blood plasma concentration levels measured using liquid chromatography-tandem mass spectrometry. The administration of LSD reduced reactivity of the left amygdala and the right medial prefrontal cortex relative to placebo during the presentation of fearful faces. There was also a significant negative correlation between LSD-induced amygdala response to fearful stimuli and the LSD-induced subjective drug effects.