2017 AAOS Annual Meeting: Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty: A Prospective Double- blinded Randomized Control Trial

82 patients scheduled for total knee arthroplasty were randomized to spinal anesthesia with or without the addition of epimorph 150ug. Patients were assessed for pain scores, narcotic consumption, and the incidence of opioid-related adverse events, such as nausea, vomiting, and pruritus, over the first 48 hours postoperatively. Results demonstrated significantly higher pain scores in the spinal epimorph group compared to the control group at 18, 24, and 48 hours postoperatively, along with higher rates of nausea and pruritus.