Local infiltration analgesia does not reduce PCA use after periacetabular osteotomy .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2014;2(13):14 Acta Orthop. 2014 Apr;85(2):141-6Seventy patients scheduled to undergo periacetabular osteotomy were randomized either to receive or not receive local infiltration analgesia (LIA) with ropivacaine intra- and postoperatively. As all patients were treated with opioid based patient-controlled analgesia (PCA) postoperatively, the purpose was to determine whether LIA was effective at reducing the need for PCA (oxycodone) postoperatively. Over the first 4 postoperative days, there was no significant difference between groups in oxycodone consumption.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Sì = 1
Incerto = 0,5
Non rilevante = 0
No = 0
La valutazione dei criteri di segnalazione valuta la trasparenza con cui gli autori riportano le caratteristiche metodologiche e sperimentali dello studio all'interno della pubblicazione. La valutazione è suddivisa in cinque categorie che vengono presentate di seguito.
1/4
Randomization
3/4
Outcome Measurements
4/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
L'Indice di Fragilità è uno strumento che aiuta l'interpretazione dei risultati significativi, fornendo una misura della forza di un risultato. L'Indice di Fragilità rappresenta il numero di eventi consecutivi che devono essere aggiunti a un risultato dicotomico per rendere il risultato non più significativo. Un numero piccolo rappresenta un risultato più debole, mentre un numero grande rappresenta un risultato più forte.
Perché questo studio era necessario ora?
Postoperative pain is often considerable following periacetabular osteotomy, requiring analgesia. Current methods of pain management include a psoas block, patient-controlled analgesia (PCA), and continuous epidural and spinal analgesia. While these treatments often lower pain experienced postoperatively, their associated side-effects have prompted researchers to consider alternative methods. Local infiltration analgesia has demonstrated efficacy in total knee and hip arthroplasty procedures, although its role in periacetabular osteotomy has yet to be established.
Qual era la domanda di ricerca principale?
What is the efficacy of local infiltration analgesia (LIA) with ropivacaine for postoperative analgesia following periacetabular osteotomy, assessed over the first 4 postoperative days?
- There were no significant differences between the LIA and placebo group for oxycodone consumption over the first 4 PODs (POD1 p=0.66; POD2 p=0.86; POD3 p=0.57; POD4 p=0.85).
- VAS pain scores at rest were similar between groups 6h after surgery and on POD 1 (p=0.1 and 0.2, respectively). The LIA group demonstrated significantly lower mean pain scores at rest than the placebo group on POD2 (24 vs. 31), POD3 (19 vs. 31) and POD4 (18 vs. 28) (p<0.05).
- No significant differences in the TUG test or pain after the TUG test were noted between groups for the duration of the 4-day observation period (all p>0.05).
- Antiemetic use was similar between groups for the duration of the placement of the catheter.
Che cosa devo ricordare di più?
Consumption of patient-controlled analgesia following periacetabular osteotomy was not decreased with the infiltration of ropivacaine at the end of surgery and for 2 days postoperatively.
Come influenzerà l'assistenza ai miei pazienti?
From these findings, it would appear that local infiltration of ropivacaine alone is not sufficient to reduce the need for patient-controlled analgesia after periacetabular osteotomy, and that adverse events associated with opioid PCA (postoperative nausea and vomiting) would not be expected to decrease from its implementation. Whether LIA ropivacaine is an efficacious component in mulitmodal analgesia for periacetabular osteotomy remains to be determined in future studies.
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