100 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to a single intraarticular injection of either triamcinolone hexacetonide 40mg or methylprednisolone acetate 40mg. Patients were assessed for outcome after 4, 12, and 24 weeks post-injection. Results for the primary outcome variable of Visual Analog Scale (VAS) pain score demonstrated no significant differences between groups at any time point, with both groups demonstrated significant reduction in pain from baseline within the first 4 weeks. Similarly, secondary outcome scores of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient's Global Assessment demonstrated no significant differences between groups, with significant within-group improvement in both groups from baseline after 4 weeks.