Similar efficacy of oral TXA to IA TXA in total knee arthroplasty without a tourniquet .
Comparison of oral versus intra-articular tranexamic acid in enhanced-recovery primary total knee arthroplasty without tourniquet application: a randomized controlled trial
BMC Musculoskelet Disord. 2018 Mar 15;19(1):85150 patients scheduled for total knee arthroplasty were randomized to either perioperative oral tranexamic acid or intraarticular tranexamic acid. Patients were assessed perioperatively for total blood loss, intraoperative blood loss, the incidence of transfusion, number of transfused units, and postoperative complications. At the 1-month and 3-month follow-ups, patients were also assessed for knee circumference, health-related quality of life, mortality, and readmission. No significant differences were observed between groups in the perioperative measures, including total blood loss, intraoperative blood loss, transfusion rate, and complication rate. Additionally, there were no significant differences between groups in outcomes at follow-up.
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