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Tranexamic acid reduces blood transfusion requirements during surgery

BMJ. 2012 May 17;344:e3054. doi: 10.1136/bmj.e3054

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Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA

Clin Orthop Relat Res. 2011 Oct;469(10):2874-80. Epub 2011 Apr 22

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Tranexamic Acid Blood Loss Blood Transfusion Oral Placebo TKA - Hide

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Tranexamic acid is effective in reducing blood loss, while maintaining safety, in THA

Arch Orthop Trauma Surg. 2013 Jul;133(7):1017-27. doi: 10.1007/s00402-013-1761-2. Epub 2013 Apr 25

Meta-analysis Arthroplasty Lower Extremity Hip Tranexamic Acid Allogenic Blood Loss Blood Transfusion Control Placebo Reduction Replacement THA TXA - Hide

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AAOS 2016: Interim evaluation of tranexamic acid vs placebo in acetabular fracture surgery

RCT Trauma Joint Acetabulum Fracture Tranexamic Acid Placebo - Hide

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TKA: Topical Fibrin Spray and Tranexamic acid reduce blood loss

J Bone Joint Surg Br. 2007 Mar;89(3):306-9

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Control Pharmacological Replacement Topical Fibrin Spray - Hide

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AAOS2017: Tranexamic acid appears safe and effective in fracture surgery

Meta-analysis Trauma Fracture Tranexamic Acid Blood Loss Orthopaedic Orthopedic Transfusion - Hide

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Efficacy of Floseal vs. tranexamic acid vs. control for bleeding control in patients undergoing TKA

Clinics (Sao Paulo). 2019 Nov 25;74:e1186.

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Control Floseal Tourniquet - Hide

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Tranexamic acid is safe and effective in reducing blood loss in TKA

J Bone Joint Surg Am. 2012 Jul 3;94(13):1153-9. doi: 10.2106/JBJS.K.00873

Meta-analysis Arthroplasty Lower Extremity Knee Tranexamic Acid Anticoagulant Blood Loss Blood Transfusion Control Placebo Pneumatic Tourniquet TKA - Hide

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3 doses of tranexamic acid more effective regimen in TKA

Clin Orthop Relat Res. 2012 Sep;470(9):2605-12. doi: 10.1007/s11999-012-2310-y. Epub 2012 Mar 15.

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Tourniquet Deflation - Hide

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AAOS 2015: No difference between topical and intravenous tranexamic acid for TKA

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Injected Intravenously Tourniquet Deflation Tourniquet Inflation - Hide

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TKR: Topical application of tranexamic acid reduces postoperative blood loss

J Bone Joint Surg Am. 2010 Nov 3;92(15):2503-13.

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Placebo Saline Solution - Hide

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AAOS 2016: TXA vs. epsilon-aminocaproic acid provide comparable outcomes after TKA

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Epsilon-Aminocaproic Acid TKA TXA - Hide

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AAOS2018: IV TXA reduced blood loss in total shoulder arthroplasty

RCT Shoulder & Elbow Upper Extremity Shoulder Tranexamic Acid Arthroplasty Blood Loss Intravenous Infusion Placebo Saline TXA - Hide

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Efficacy of various tranexamic acid administration techniques to reduce blood loss in TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Dec;22(12):3181-90.

Meta-analysis Arthroplasty Lower Extremity Knee Tranexamic Acid Injection Blood Loss Control Information Intravenous TXA Placebo TKA Transfusion - Hide

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