Tranexamic acid reduces blood transfusion requirements during surgery

BMJ. 2012 May 17;344:e3054. doi: 10.1136/bmj.e3054

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA

Clin Orthop Relat Res. 2011 Oct;469(10):2874-80. Epub 2011 Apr 22

Tranexamic acid is effective in reducing blood loss, while maintaining safety, in THA

Arch Orthop Trauma Surg. 2013 Jul;133(7):1017-27. doi: 10.1007/s00402-013-1761-2. Epub 2013 Apr 25

AAOS 2016: Interim evaluation of tranexamic acid vs placebo in acetabular fracture surgery

AAOS2017: Tranexamic acid appears safe and effective in fracture surgery

TKA: Topical Fibrin Spray and Tranexamic acid reduce blood loss

J Bone Joint Surg Br. 2007 Mar;89(3):306-9

Tranexamic acid is safe and effective in reducing blood loss in TKA

J Bone Joint Surg Am. 2012 Jul 3;94(13):1153-9. doi: 10.2106/JBJS.K.00873

AAOS 2015: Tranexamic acid effectively lowers blood loss following TKA without tourniquet

AAOS 2016: TXA vs. epsilon-aminocaproic acid provide comparable outcomes after TKA

3 doses of tranexamic acid more effective regimen in TKA

Clin Orthop Relat Res. 2012 Sep;470(9):2605-12. doi: 10.1007/s11999-012-2310-y. Epub 2012 Mar 15.

AAOS: Tranexamic acid equally effective when administered topically & intravenously in TKA

AAOS2018: IV TXA reduced blood loss in total shoulder arthroplasty

Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

Equivalent blood conservation with intra-articular and intravenous TXA in TKA

J Bone Joint Surg Am. 2014 Dec 3;96(23):1937-44

Efficacy of various tranexamic acid administration techniques to reduce blood loss in TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Dec;22(12):3181-90.

Intravenous TXA prior to tourniquet inflation more efficacious compared to later timepoints

J Arthroplasty. 2017 Jan;32(1):33-36

Tranexamic acid effectively reduces blood loss after TKA without adverse events

Knee Surg Sports Traumatol Arthrosc. 2014 Aug;22(8):1849-58

AAOS 2015: No difference between topical and intravenous tranexamic acid for TKA