Michelle Gert reflects on a career shaped by scientific curiosity, a transition from basic science to global clinical trials, and mentorship that enabled her to launch major RCTs in orthopedic oncology. She describes navigating U.S.–Canadian research cultures, emphasizing how resource-rich systems fuel ambition while lower-resource environments build efficiency and resilience. Her global network, spanning South America, India, South Africa, and beyond, shows how surgeon-driven engagement and modest site support can deliver high-quality data. Looking ahead, she sees technology as both catalyst and threat—expanding global collaboration while challenging journals to safeguard integrity in an era of AI-generated content.