Dr. Sheila Sprague and Dr. Samir Paia dive into what makes great orthopaedic research stand out—from designing feasible RCTs and crafting precise PICOT questions to avoiding the common methodological traps that can’t be fixed in revision. They unpack the growing interest in Bayesian analysis, emphasizing the importance of justified priors, transparent reporting, and rigorous study conduct. With practical advice on how to write clear, methodologically sound papers that meet top-tier journal standards, this discussion is a must-listen for researchers aiming to turn solid science into publishable, practice-changing evidence.