Top Evidence Trends from 2022: Clinical Trials that Moved the Needle .

Which trials in 2022 truly moved the needle in orthopaedics? From skin antiseptics in open fractures (Aqueous-PREP) to thromboprophylaxis after arthroplasty (CRISTAL), cement use in hip fracture (WHiTE 5), antibiotic duration in oncology (PARITY), opioid reduction strategies (NO PAin), and ACL treatment pathways (ACL SNNAP), this OE Insight highlights a powerful lineup of RCTs that challenge assumptions and reshape practice. These studies reflect a growing maturity in orthopaedic trial design—and reveal where the future of evidence-based surgical care is headed.