Orthopaedic research in 2024 marked a shift in focus, with extremity care and sports medicine drawing more attention than arthroplasty. Landmark studies highlighted iodine-alcohol antisepsis reducing surgical site infections, combined strength and balance training improving chronic ankle instability, and rapid rehabilitation lowering complications after hip fractures. Explorers—those at the forefront of research—showed heightened interest in platelet-rich plasma formulations, digital rehabilitation strategies, and long-term outcomes of surgical innovations. Looking to 2025, the field is set to expand into AI-assisted imaging and diagnostics, 3D-printed custom implants, and the growing role of digitized care. Meanwhile, GLP-1 therapies for weight loss may emerge as powerful tools in perioperative management and osteoarthritis prevention. Together, these trends suggest a rapidly evolving landscape where biologics, technology, and digital health converge to redefine musculoskeletal care.