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RESEARCH
Largest Trial of Skin Antiseptics in Complex Fractures .
OrthoEvidence Journal (OE Journal) - OE Original
OE Journal. 2022;10(19):4In one of the largest RCTs to date on open fracture care, the Aqueous-PREP trial examined whether antiseptic skin preparation influences surgical site infection risk. Conducted across 14 hospitals in three countries, over 1,600 patients were randomized to aqueous 10% povidone-iodine or 4% chlorhexidine gluconate. Infection and reoperation rates were similar, challenging long-held preferences and questioning assumptions drawn from non-orthopaedic surgery. Beyond clinical outcomes, this study showcased patient-engaged trial design and multinational collaboration—setting a new benchmark for pragmatic trauma research.
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