OE JOURNAL
OE Journal
Vol. 14 | Iss. 18 | September 2026 - 45 Studies
Questions This Issue Explores
In adults with knee OA, did intra-articular LR-PRP injections, compared with intra-articular HA injections, improve pain, WOMAC outcomes, and safety at 1, 3, 6, and 12 months after treatment?
In adults with KOA, did an 8-week SHEP, combined with lifestyle advice, improve pain and physical function compared with pain medication and lifestyle advice, as measured at 8 weeks?
In adults with CRCI, did ultrasound-guided corticosteroid and local anaesthetic injections followed by digital rehabilitation, compared with the same injections followed by conventional rehabilitation exercises, improve shoulder function, pain, and ROM over 3 months?
In adults with isolated closed distal radius fractures requiring surgical fixation, did MIPO, compared with conventional volar locking plate fixation, both performed under WALANT, reduce POD1 pain and improve functional, cosmetic, and radiographic outcomes over 6 months?
In patients undergoing arthroscopic rotator cuff repair, did high-dose platelet-rich plasma augmentation, compared with low-dose platelet-rich plasma augmentation, improve postoperative pain, shoulder function, and retear rates at ≥1 year follow-up?
EDITOR'S PICK 
Platelet Concentration Does Not Influence Clinical Efficacy and Retear Rates of Rotator Cuff Repair
10 RCTs, including 696 patients undergoing rotator cuff repair (RCR), were included in this systematic review and meta-analysis evaluating platelet-rich plasma (PRP) augmentation and comparing outcomes according to high-dose versus low-dose PRP. High-dose PRP was defined as a platelet concentration >4 times that of whole blood, while low-dose PRP was defined as <4 times baseline concentration. Pooled outcomes included visual analogue scale (VAS) pain scores, Constant-Murley (CM) scores, American Shoulder and Elbow Surgeons (ASES) scores, University of California–Los Angeles (UCLA) shoulder scores, and rotator cuff retear rates. Overall, PRP augmentation was associated with lower pain, improved CM scores, and lower retear rates compared with RCR alone; however, subgroup and meta-regression analyses found no significant relationship between platelet dose and any clinical outcome or retear rate. These findings suggested that increasing platelet concentration beyond 4 times baseline did not provide additional clinical or structural benefit following RCR.
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