PRP Injection 6 Months Before Total Shoulder Arthroplasty May Increase Infection Risk .

Platelet-rich plasma (PRP) injections administered within six months prior to total shoulder arthroplasty may be associated with an increased risk of postoperative infection. Findings suggest that patients receiving PRP closer to the time of surgery demonstrated higher infection rates compared with those who did not undergo preoperative biologic injection. Although PRP is commonly used to manage shoulder pain and degenerative conditions, the results raise important considerations regarding the timing of biologic therapies before joint replacement. These findings highlight the need for careful perioperative planning and may support establishing optimal intervals between intra-articular injections and arthroplasty to reduce infection risk and improve surgical outcomes.