The article highlights six emerging orthopedic startups that are introducing innovative technologies and solutions across a range of musculoskeletal care areas, including regenerative medicine, joint preservation, trauma care, AI-enhanced imaging, personalized spine surgery, and implant design. It profiles ReGelTec, which is developing a percutaneous hydrogel implant for degenerative disc disease that has shown notable pain and disability score improvements; BlueOcean Global, whose modular Excelsior External Fixation System supports complex limb reconstruction; See All AI, offering an AI-driven platform that converts standard fluoroscopic images into high-resolution 3D models for intraoperative guidance; OSSTEC, advancing 3D-printed cementless partial knee implants to expand partial knee use; Phoenix Kinetics, developing a non-fixated, load-sharing meniscus implant with Breakthrough Device status; Nivalon Medical, creating fully patient-specific, metal-free motion-preserving spinal implants; and Forma Medical, whose minimally invasive OptimalMTP system facilitates faster metatarsophalangeal joint fusions and related procedures. These startups exemplify the next wave of orthopedic innovation addressing clinical gaps and unmet patient needs in 2026.