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RCT
ACE Report #9811
Ace Report Cover Osteoarthritis

Rofecoxib and celecoxib demonstrate similar, significant 6-week efficacy vs placebo in OA treatment


Study Type:Therapy
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Efficacy and safety of rofecoxib 12.5 mg and celecoxib 200 mg in two similarly designed osteoarthritis studies

Curr Med Res Opin. 2006 Jan;22(1):199-210

Contributing Authors: AM Tershakovec DJ Chang C Birbara G Ruoff E Sheldon C Valenzuela A Rodgers RA Petruschke

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Synopsis

808 patients, combined from two trials, with knee osteoarthritis were randomized to receive either celecoxib 200mg daily, rofecoxib 12.5mg daily, or placebo. Patients were assessed over a 6-week period of treatment on a Patient Global Assessment of Response to Therapy (PGART), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Physical Function subscales, and the i...

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