Efficacy of topical diclofenac preparation in managing symptomatic knee osteoarthritis .
Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial
CMAJ. 2004 Aug 17;171(4):333-8248 patients with symptomatic knee osteoarthritis were randomized to one of three treatment groups: topical diclofenac sodium gel, a vehicle-control group that administered only the carrier solution, and a placebo group. Patients were to apply the allocated interventions for 4 weeks. Patients were assessed for outcome on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), a Patient Global Assessment, and the Incidence of adverse events. After 4 weeks, reduction in each of the WOMAC Pain, Physical Function, and Stiffness subscales was significantly greater in the topical diclofenac group compared to both the vehicle-control group and the placebo group.
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