Combined Topical & IV TXA superior to topical TXA alone for reducing blood loss in TKA
The Efficacy of Combined Use of Intraarticular and Intravenous Tranexamic Acid on Reducing Blood Loss and Transfusion Rate in Total Knee ArthroplastyJ Arthroplasty. 2015 May;30(5):776-80
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One hundred and twenty patients with a diagnosis of primary osteoarthritis (OA) scheduled for unilateral total knee arthroplasty were randomized to receive either a combination of topical and intravenous administration of tranexamic acid, topical administration alone, or a saline control. Initial hemoglobin levels and postoperative drop, total drain amount, total blood loss, and transfusion rate w...
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