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ACE Report #5931
Ace Report Cover Metabolic Disorders

Prostate cancer: Zoledronic acid as an adjuvant therapy is well-tolerated and improves BMD


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

RTOG 0518: randomized phase III trial to evaluate zoledronic acid for prevention of osteoporosis and associated fractures in prostate cancer patients

Prostate Cancer Prostatic Dis. 2013 Dec;16(4):382-6. doi: 10.1038/pcan.2013.35. Epub 2013 Oct 1

Contributing Authors: LA Kachnic SL Pugh P Tai M Smith E Gore AB Shah AG Martin HE Kim A Nabid CA Lawton

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Synopsis

109 patients with nonmetastatic prostate cancer, undergoing androgen deprivation therapy (ADT) in combination with radiotherapy (RT), were randomized to receive a 4-mg infusion of zoledronic acid every 6 months for 3 years, as well as vitamin D and calcium supplements, or supplements alone. The purpose of this study was to examine the safety and efficacy of zoledronic acid with respect to the inci...

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