75 mg risedronate once-monthly appears well tolerated in Japanese osteoporosis patients .
This report has been verified
by one or more authors of the
original publication.
Efficacy, tolerability and safety of once-monthly administration of 75 mg risedronate in Japanese patients with involutional osteoporosis: A comparison with a 2.5 mg once-daily dosage regimen
Bone. 2014 Feb;59:44-52. doi: 10.1016/j.bone.2013.10.017. Epub 2013 Oct 29.852 Japanese patients with involutional osteoporosis were randomized to receive 75 mg oral risedronate once-monthly or 2.5 mg oral risedronate once-daily, with the purpose of comparing the efficacy, tolerability, and safety of both treatment options. Upon analysis, results indicated that 75 mg risedronate tablets taken once a month achieved similar bone mineral density and fracture rates compared to 2.5 mg risedronate tablets taken once a day. Urinary NTX/CRN and CTX/CRN bone markers decreased significantly in both groups, but resulted in a more pronounced reduction in the 2.5 mg once-daily risedronate group, while acute phase reaction adverse events were higher in the 75 mg once-monthly risedronate group.
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