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Tranexamic Acid Reduces Blood Loss in Pediatric Osteogenesis Imperfecta Femoral Nailing

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Ace Report Cover
October 2025

Tranexamic Acid Reduces Blood Loss in Pediatric Osteogenesis Imperfecta Femoral Nailing

Vol: 307| Issue: 10| Number:95| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Efficacy of intraoperative use of tranexamic acid in reducing blood loss from telescoping nail application in osteogenesis imperfecta. A randomized controlled trial.

Orthop Traumatol Surg Res. 2025 01-May;().

Contributing Authors:
HM Elbaseet AJ Aldeen AKH Irahim

Synopsis

Forty patients with osteogenesis imperfecta (OI) were randomized to receive intraoperative tranexamic acid (intravenous plus topical) (n=20) or no tranexamic acid (n=20). The primary outcome was total blood loss. Secondary outcomes included changes in hemoglobin and hematocrit, transfusion rate, operative time, and short-term TXA-related complications. Outcomes were assessed intraoperatively and t...

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