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Comparison of the Effects of Metformin & Thiazolidinediones on Bone Metabolism: A Meta-Analysis

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Ace Report Cover
June 2024

Comparison of the Effects of Metformin & Thiazolidinediones on Bone Metabolism: A Meta-Analysis

Vol: 306| Issue: 6| Number:43| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Comparison of the Effects of Metformin and Thiazolidinediones on Bone Metabolism: A Systematic Review and Meta-Analysis.

Medicina (Kaunas) . 2023 May 8;59(5):904.

Contributing Authors:
RD Chen CW Yang QR Zhu Y Li HF Hu DC Wang SJ Han

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Synopsis

Seven randomized controlled trials, including 1656 patients with diabetes mellitus, were included in this systematic review and meta-analysis comparing metformin versus thiazolidinediones (TZDs). Pooled outcomes of interest included bone mineral density (BMD), C-terminal telopeptide of type I collagen (CTX), procollagen type I N-terminal propeptide (PINP), bone-specific alkaline phosphatase (BAP),...

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