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Vol:239 Issue:1 Number:1 ISSN#:2564-2537
Author Verified
RCT
ACE Report #14650
Ace Report Cover Trauma

Effect of Leukocyte-Reduced Platelet-Rich Plasma On Synovial Fluid Biomarkers After Pilon Fractures


How to Cite

OrthoEvidence. Effect of Leukocyte-Reduced Platelet-Rich Plasma On Synovial Fluid Biomarkers After Pilon Fractures. ACE Report. 2022;239(1):1. Available from: https://myorthoevidence.com/AceReport/Report/14650

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

A prospective randomized double-blind clinical trial to assess the effects of leukocyte-reduced platelet-rich plasma on pro-inflammatory, degradative, and anabolic biomarkers after closed pilon fractures.

J Orthop Res . 2022 Apr;40(4):925-932

Contributing Authors:
BP Zitsch CR James BD Crist AM Stoker GJ Della Rocca JL Cook

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Synopsis

Eleven patients undergoing two-staged open reduction and internal fixation (ORIF) of an isolated pilon fracture were randomized to receive either 5ml of either autogenous leukocyte-reduce platelet-rich plasma (PRP) (n=5) or sterile 0.9% saline (n=6). The primary outcomes of this trial were to assess the number of post-traumatic osteoarthritis (PTOA)-related pro-inflammatory degradative biomarkers ...

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