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Vol:239 Issue:2 Number:1 ISSN#:2564-2537
ACE Report #14647
Ace Report Cover Arthroplasty

Oral Mecobalamin Does Not Reduce Incisional Skin Numbness After Total Knee Arthroplasty

How to Cite

OrthoEvidence. Oral Mecobalamin Does Not Reduce Incisional Skin Numbness After Total Knee Arthroplasty. ACE Report. 2022;239(2):1. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

No Effect of Oral Mecobalamin on Skin Numbness at 3 Months After Total Knee Arthroplasty: A Randomized, Double-Blinded, Placebo-Controlled Superiority Trial.

JB JS Open Access . 2022 Apr 8;7(2):e22.00002. doi: 10.2106/JBJS.OA.22.00002.

Contributing Authors:
P Ruangsomboon S Nepal P Udomkiat A Unnanuntana

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One hundred and fifty four patients undergoing total knee arthroplasty were randomized to receive mecobalamin (n=77) or placebo (n=77). The primary outcome of interest was the change in area of numbness around the surgical site from 2 weeks to 3 months following TKA. Secondary outcomes included the rates of different adverse events, functional outcomes measured by the modified Knee Society Clinica...

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