Zoledronic acid reduces rates of new clinical fractures after hip fracture repair .
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Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture
N Engl J Med. 2007 Nov 1;357(18):1799-809. Epub 2007 Sep 17
2127 patients were randomized to one of two groups to examine the rates of new clinical fractures after hip fracture repair. The first group received an annual infusion of zoledronic acid (a potent bisphosphonate), while the second group received a placebo. Results indicated that an annual infusion of zoledronic acid is associated with reduced rates of new clinical fractures and subsequently, morbidity.
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