60 patients who underwent bilateral total knee arthroplasty who underwent the procedure at least 4 years prior to the initiation of this study were randomized to one of two exercise groups: an exercise regimen with progressive and weighted isometric/isotonic exercises or an exercise regimen without weight resistance. The purpose of this study was to determine if weighted home exercise therapy was associated with significantly improved pain, function, and lower extremity muscle strength when compare to non-weight exercise therapy after 8 weeks. Results demonstrated that although pain experienced at rest and ROM remained comparable between groups at 8 weeks, significantly improved pain during activity, muscle strength in the quadriceps femoris and hamstring muscles, functional performance, and HSS knee scores were observed in the weighted exercise group after termination of therapy when compared to the non-weighted group.