Vitamin D supplementation has no major impact on knee OA symptoms or progression .
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial
JAMA. 2013 Jan 9;309(2):155-62. doi: 10.1001/jama.2012.164487146 patients were randomized to evaluate the effect of vitamin D supplementation on the symptoms and structural progression of knee osteoarthritis (OA). Patients with knee OA received either placebo or oral cholecalciferol (2000 IU/d) and were assessed after 2 years. Results revealed that vitamin D supplementation for 2 years did not reduce knee pain or cartilage volume loss in comparison to the placebo.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics