Vitamin D supplementation following hip fracture: what is the best dosing strategy ?
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A randomized controlled trial of vitamin D dosing strategies after acute hip fracture: no advantage of loading doses over daily supplementation
BMC Musculoskelet Disord. 2011 Jun 20;12:135. doi: 10.1186/1471-2474-12-13565 patients who had recently suffered an acute hip fracture were randomized to determine the effect of a vitamin D2 loading dose on serum 25-hydroxyvitamin D3 (25-OHD) levels. Patients were allocated to receive one of three loading doses on top of vitamin D3 supplementation: either a high-loading dose (100000 IU), a low-loading dose (50000 IU), or a placebo loading dose. Results after 3 months indicated that there was no significant effect of either active loading dose on serum 25-OHD levels.
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