Vancomycin Versus Cefazolin in the Prevention of Surgical Site Infections Following TKA .
Is Topical Vancomycin an Option? A Randomized Controlled Trial to Determine the Safety of the Topical Use of Vancomycin Powder in Preventing Postoperative Infections in Total Knee Arthroplasty, as Compared With Standard Postoperative Antibiotics.
J Arthroplasty . 2023 Aug;38(8):1597-1601.e1.165 patients undergoing total knee arthroplasty were randomized to receive either vancomycin (n=80) or cefazolin (n=85). The primary outcome of this trial was the incidence of surgical site infections (SSI) after 42 postoperative days. Secondary outcomes of interest include length of stay, the incidence of postoperative myocardial infarction (MI), pulmonary embolism (PE), urinary tract infection, or blood transfusions. The vancomycin group had significantly more SSI in 42 postoperative days compared to the cefazolin group. Secondary outcomes were comparable between the two groups.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
