Eighty-eight patients undergoing posterior cervical laminectomy for myelopathy were randomized to receive either an ultrasound-guided inter-semispinal plane block with multimodal analgesia (n=44) or multimodal analgesia alone (n=44). The primary outcome was perioperative opioid consumption. Secondary outcomes included intraoperative muscle relaxant use, surgical duration, blood loss, postoperative pain scores, alertness, ambulation time, satisfaction scores, and complications. Outcomes were assessed up to 72 hours postoperatively. Overall, the results of the study revealed that the ISPB group had significantly reduced opioid and muscle relaxant requirements, shorter operative time, lower blood loss, better pain control, faster ambulation, and higher satisfaction. These findings suggest that the ISP block is a safe and effective addition to multimodal analgesia for cervical laminectomy.