Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA .
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial
Clin Orthop Relat Res. 2011 Oct;469(10):2874-80. Epub 2011 Apr 22100 patients with primary osteoarthritis who were scheduled to undergo unilateral cemented total knee arthroplasty were randomized to receive either placebo or intravenous tranexamic acid 10 minutes prior to surgery, 3 hours after surgery, and orally for 5 days after surgery. Patients who received tranexamic acid displayed significantly less blood loss, hemoglobin loss, and required significantly less blood transfusion in comparison to patients who received placebo. Additionally, no changes were observed in symptomatic thromboembolic events.
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